Review Article
Year: 2021 | Month: August | Volume: 8 | Issue: 8 | Pages: 628-635
DOI: https://doi.org/10.52403/ijrr.20210883
MicroRNA-125b as a Preeclampsia Biomarker
Bryan Gervais de Liyis1, Angela Faustine Ciaves1, Elliana Freya Hernowo1, Wilson Halim1, Desak Made Wihandani2
1Faculty of Medicine, Udayana University, Denpasar, Bali, Indonesia
2Department of Biochemistry, Faculty of Medicine, Udayana University, Denpasar, Bali, Indonesia
Corresponding Author: Bryan Gervais de Liyis
ABSTRACT
Pregnancy hypertensive disorder (PHD) is a broad term referring to conditions related to disorders of high blood pressure during pregnancy. Preeclampsia is one of 4 types of PHD characterized by an increase in systolic blood pressure ≤ 140 mmHg with a diastolic pressure ≤ 90 mmHg accompanied by proteinuria of 1+ or more. Complications of PHD include peripartum cardiomyopathy, maternal mortality, pulmonary edema, cerebrovascular accident and renal failure. As consequence, early detection of PHD is crucial in preventing complications. “Preeclampsia”, “microRNA-125b” and “Biomarker” were the keywords applied to scientific online databases, such as ScienceDirect, PubMed, and Researchgate. A total of 46 journals were screened, reviewed and utilized with utmost precision to construct this literature review. Looking at the dangers of preeclampsia on infants and mothers, miRNA-125b has potential to be used as a biomarker of preeclampsia that can occur in the third trimester. The increase in the concentration of miRNA-125b in the first trimester causes inhibition of trophoblast invasion, which is followed by inhibition of KCNA1, GPC1, and SGPL1. All of these proteins play a role in the invasion trophoblast which is also exacerbated by the increase in the concentration of mir-125b. All in all, these symptoms and the increase of mir-125b that appear in the first trimester yield as a promising result as biomarkers of preeclampsia in the third trimester.
Keywords: preeclampsia, microRNA-125b, biomarker, SGPL1, maternal, infants.
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