Case Report
Year: 2021 | Month: November | Volume: 8 | Issue: 11 | Pages: 282-285
DOI: https://doi.org/10.52403/ijrr.20211136
Late Onset Alzheimer Dementia in Patient with Genotype E3/E4: A Case Report
Irfan Kurnia Kaban1, Yudha Haryono1
1Department of Neurology, Faculty of Medicine Airlangga University, Airlangga University Hospital, Surabaya, Indonesia
Corresponding Author: Irfan Kurnia Kaban
ABSTRACT
Background: Alzheimer's dementia (AD) is a neurodegenerative disorder and there is progressive cognitive impairment, functional deficits and behavioral changes. This neurodegenerative disease process is classically characterized by two pathological features: amyloid- β plaque deposition and neurofibrillary tangle of tau hyperphosphorylation. The most established genetic risk factor for late-onset Alzheimer Disease is the APOE gene allele 4. We will report a case of late-onset Alzheimer's Dementia with genotype E3/E4.
Case: A 70-years-old woman patient, complained by her family that she often forgets. The Mini Mental State Examination showed disturbances in orientation, attention, calculation and recall. Non-contrast Brain Magnetic resonance imaging examination revealed decrease in hippocampal volume. Patient also performed a molecular examination of the Apolipoprotein E (APOE) genotype and the genotype E3/E4 was detected
Conclusion: The APOE E4 gene has a major role in the occurrence of Late-Onset Alzheimer's Dementia.
Keywords: Alzheimer Dementia, Apolipoprotein E.
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