Original Research Article
Year: 2020 | Month: May | Volume: 7 | Issue: 5 | Pages: 50-53
Impact of Various Socio-Demographic Factors, BCG Scar and History of Contact on CBNAAT Detecting CNS Tuberculosis
Dhrmendar Rawat1, Hemlata Bakolia2, Daya Lal Solanki3
1Senior Resident, Department of Pediatrics, AIIMS, Jodhpur.
2Senior Resident, Department of Ophthalmology, JLN Medical College, Ajmer.
3Junior Specialist, Department of Pediatrics, CHC Masuda, Ajmer.
Corresponding Author: Daya Lal Solanki
ABSTRACT
Aim: To evaluate the impact of various socio-demographic factors, BCG Scar and history of contact on CBNAAT detecting CNS tuberculosis
Material and method: The present was conducted from July 2017 to June 2018 in Department of Paediatrics, JLN Medical College and associated group of Hospitals, Ajmer. All the selected patients were subjected to detailed history, general physical examination, systemic examination, hematological investigations (level of hemoglobin, total leukocyte count, and differential leukocyte count, and erythrocyte sedimentation rate), radiological investigations (chest X-ray, USG cranium, cranial CT, and magnetic resonance imaging), tuberculin sensitivity test (performed by intradermal injection of 0.1 ml purified protein derivative [PPD] containing 5 tuberculin units [PPD-5] into the volar [ventral] surface of forearm by a disposable plastic tuberculin syringe), and CSF for culture and sensitivity (gold standard) and for CBNAAT (with use of quality controls).
Results: It was found that that rpoB gene of Mycobacterium tuberculosis was detected by Cartridge based nucleic acid amplification test in 66.7% of children among 0-5 yrs age group, in 40 % of females and 51.4 % of males. rpoB gene was detected by Cartridge based nucleic acid amplification test in 57.1% of patients with positive BCG scar and 42.9% of patients with absent BCG scar with a p-value of 0.02 which shows significant statistical difference.
Conclusion: It can be concluded that CBNAAT was affected by history of contact and BCG scar.
Keywords: CNS, Tuberculosis, Children
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