Original Research Article
Year: 2020 | Month: March | Volume: 7 | Issue: 3 | Pages: 448-452
An Observational Study to Evaluate the Effect of Different Dosage of Metformin on Serum Vitamin B12 in a Cohort of Eastern Indian Type 2 Diabetes Subjects
Arjun Baidya
Associate Professor, Department of Endocrinology, Nil Ratan Sircar Medical College & Hospital, Kolkata
ABSTRACT
Aim: Vitamin B12 deficiency is one of the major and common problem in subject with type 2 diabetes and this situation might get worsened in subjects who are on metformin therapy. The main aim of this study was to evaluate the effect of different dosage of metformin on serum Vitamin B12 in Indian Type 2 Diabetes (T2DM) subjects.
Methods: This observational study was carried out in a tertiary care clinic where 365 patients were treated with metformin ≤ 1000 mg for at least 3 years (5± 0.9) and 360 patients were on metformin ≥ 1500 mg at least 3 years (5± 0.8). Demographical data was recorded in a predesigned format and blood glucose level was performed in a NABL accelerated pathological laboratory. Serum vitamin B12 was measured by using an immunoassay method.
Results: Mean serum vitamin B12 levels in subjects who received higher dose of metformin (≥1500 mg) (259.19 ± 123.02) were significantly lower than in subjects who received lower dose of metformin (≤ 1000 mg) (307.31 ± 107.9) (p value 0.037). In addition, mean vitamin B12 in serum levels was found to be in vegetarians (321.13±103.04) were significantly lower than B12 in serum levels was found to be in non-vegetarian (389.41±105.9) (p value 0.01).
Conclusion: Among T2DM patients on metformin therapy vitamin B12 deficiency is high. Lowering levels of vitamin B12 is directly related to higher dose of metformin.
Keywords: Metformin, Serum Vitamin B12, Type 2 Diabetes (T2DM), Eastern Indian.
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