Review Article
Year: 2019 | Month: December | Volume: 6 | Issue: 12 | Pages: 360-364
Role of Glutathione Peroxidase [GPx] in Peripheral Neuropathy: A Critical Update on Clinical and Experimental Studies
Mohammed Zoheb1, Zareena Parveen3, Arshiya Afreen3, Shafia Siddiqui3, Tanveer Yousra3, Sadiya Mustafavi3, Mohd Mohiuddin4, Mohd Ishaq2
1Assistant Professor Department of Neurology, Deccan College of Medical Sciences, Princess Esra Hospital, Hyderabad.
2Professor and Head of Department of Salar-e-Millat Sultan Salah Uddin Owaisi Research Centre for Cellular and Molecularmedicine, Princess Esra Hospital, Hyderabad.
3Department of Pharmacy Practice, Deccan School of Pharmacy, Aghapura, Hyderabad.
4Department of Pharmacology, Deccan School of Pharmacy, Aghapura, Hyderabad.
Corresponding Author: Mohd Ishaq
ABSTRACT
Glutathione peroxidase, a Selenium containing enzyme, protects the cells by acting as an antioxidant and neutralizing free radicals. The present review highlights the role of Glutathione Peroxidase in Diabetic Peripheral Neuropathy as well as some of the Neurodegenerative disorders like Alzheimer’s Disease and Parkinson’s disease which contributes to increase mortality and effecting quality of life in many individuals throughout the World. However, the role of Glutathione peroxidase is found important even in animals. Various studies showed that Gpx1gene knockout experiment in mice leads to Diabetic Peripheral Neuropathy. The mice found deficient in cellular GPx show no increased sensitivity to Hyperoxia and apart from this deficiency of Gpx1 accelerates the progression of Atherosclerosis in Apolipoproteins E-deficient mice.
Key words: Glutathione peroxidase, Diabetic Peripheral Neuropathy.
[PDF Full Text]