Original Research Article
Year: 2019 | Month: December | Volume: 6 | Issue: 12 | Pages: 17-21
Correlation between CRP and Atherogenic Index and Assessment of Cardiovascular Disease Risk in Patients with Rheumatic Arthritis
Sabira Dabeer1, Neha Sharma2, Abhay Nagdeote3
1,2Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.
3 ESI-PGIMSR and Model Hospital, Andheri, Mumbai, Maharashtra, India.
Corresponding Author: Dr Sabira Dabeer
ABSTRACT
Background- Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease, which affects approximately 1-2% of the world’s population with an annual incidence rate of between 0.5% and 1%. Most common cause of morbidity and mortality in RA is cardiovascular disease.
Aim & Objective-: To find out atherogenic index (AIP) in patients with RA and study the correlation between CRP(C- reactive protein) and AIP.
Methods:- A prospective cross sectional observational study was done in biochemistry department of ESIPGIMSR & Model hospital Andheri Mumbai from January 2015 to August 2016.This study involved 100 subjects between the age group of 30-50 years, including age and sex matched control. Parameters included were RA factor, anti-ACCP, CRP, ESR and fasting lipid profile (HDL-C, LDL-C, TG, VLDL-C and total cholesterol).
Results:-Deranged lipid profile with high AIP (0.52±0.14) and a positive Pearson coefficient of correlation (r= 0.98) between AIP and CRP was found in patients with rheumatoid arthritis.
Conclusion: - Chronic inflammation in rheumatoid arthritis causes dyslipidemia leading to high risk of cardiovascular diseases in RA patients.
Key words: Dyslipidemia, atherosclerosis, cardiovascular diseases, inflammation, Rheumatoid arthritis
[PDF Full Text]