Year: 2026 | Month: May | Volume: 13 | Issue: 5 | Pages: 814-823
DOI: https://doi.org/10.52403/ijrr.20260582
Evidence of Cardiac Manifestations and Their Correlation with Biochemical Parameters in Covid‑19 Patients: A Prospective Observational Study
Dr. Suraj Kashid1, Dr. Lakshmi Spandana Potluri2, Dr. T R Raghu3, Dr. Saanvi Suryavanshi4
1Senior Resident, Department of Cardiology, Rajarajeswari Medical College and Hospital
2Senior Resident, Department of Cardiology, Rajarajeswari Medical College and Hospital
3Professor And Hod, Department of Cardiology, Rajarajeswari Medical College and Hospital
4Assistant Professor, Department of Radiology, Rajarajeswari Medical College and Hospital
Corresponding Author: Dr. Suraj Kashid
ABSTRACT
Background: Coronavirus disease 2019 (COVID-19) is associated with significant cardiovascular involvement including myocarditis, myocardial infarction, arrhythmias, heart failure, and thromboembolic complications. [1-5] Cardiac injury in COVID-19 has been linked to inflammatory and biochemical markers such as CRP, ferritin, D-dimer, LDH, neutrophil-lymphocyte ratio (NLR), troponin I, CK-MB, and BNP. [6-8]
Aim: To study the spectrum of cardiac manifestations in COVID-19 patients and correlate these manifestations with biochemical and inflammatory parameters.
Materials and Methods: This hospital-based prospective observational study was conducted at a tertiary care hospital from 1 February 2024 to 31 January 2026. A total of 108 confirmed COVID-19 patients with cardiac manifestations were included. Demographic data, clinical findings, biochemical markers, lipid profile, cardiac biomarkers, echocardiographic findings, and outcomes were analyzed. Statistical significance was considered at p<0.05.
Results: The mean age of participants was 54.3 ± 6.1 years. Males constituted 61.1% of the study population. The most common cardiac manifestation was myocarditis (38.9%), followed by myocardial infarction and arrhythmias (20.4% each). Troponin I positivity was observed in 41.7% patients. Elevated inflammatory markers including CRP, ESR, ferritin, LDH, D-dimer, and NLR showed significant association with myocarditis and myocardial infarction (p<0.05). BNP and CK-MB levels were significantly elevated in myocarditis and heart failure. Mortality was observed in 29.7% patients.
Conclusion: COVID-19 is associated with diverse cardiac manifestations, with myocarditis being the most common in the present study. Elevated inflammatory and cardiac biomarkers strongly correlate with myocardial injury and adverse outcomes. [7-9]
Keywords: COVID-19, myocarditis, myocardial infarction, arrhythmia, biomarkers, troponin I.
[PDF Full Text]