Year: 2026 | Month: April | Volume: 13 | Issue: 4 | Pages: 269-277
DOI: https://doi.org/10.52403/ijrr.20260426
Comparative Study of Procalcitonin/Albumin Ratio, Lactate /Albumin Ratio and CRP/Albumin Ratio in Pediatrics Sepsis Cases
Mahadevaiah V1, Meera. K. S.2
1MBBS, MD. Senior Resident, Department of Paediatrics, Chandramma Dayananda Sagar Institute of Medical Education and Research. Bengaluru, Karnataka, India.
2MBBS, MD. Professor, Department of Biochemistry, Ramaiah Medical College and Hospital. Bengaluru, Karnataka, India.
Corresponding Author: Dr. K. S. Meera
ABSTRACT
Introduction: Sepsis is a life-threatening condition that happens when the body’s immune system has an extreme response to an infection, causing organ dysfunction. Paediatric sepsis in India is a major public health crisis, causing high mortality (25–30%) and significant morbidity, largely driven by malnutrition, delayed care, and infection.
Objective: The present study was taken up to do a comparative study of PAR, LAR and CAR in paediatric sepsis cases and their significance with the conventional biomarker the C-reactive protein and procalcitonin.
Material and methods: A prospective observational study of 74 clinically diagnosed sepsis cases, admitted to paediatric ICU were analysed Along with sepsis panel, lactate, albumin, CRP and PCT were estimated at the time of admission.
Results: The study sample comprised 43 cases with sepsis and 31 cases with severe sepsis. The mean values of TLC, albumin, procalcitonin and C-reactive protein in severe sepsis were significantly higher in comparison to sepsis cases with p value <0.001. The values of PAR and CAR were significantly (p<0.001) raised in severe sepsis cases. The rise in LAR was statistically significant (p<0.05) raised in severe sepsis cases as compared to sepsis cases. There was no significant correlation between CAR, LAR and PAR in both sepsis and severe sepsis cases.
Interpretation and Conclusion: PAR, CAR and LAR are independent indicators of systemic inflammation that aid in the severity assessment and prognostic prediction of sepsis-related outcomes.
Keywords: Albumin, CRP/albumin ratio, Lactate/albumin ratio, Procalcitonin/albumin ratio sepsis.
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