Year: 2026 | Month: March | Volume: 13 | Issue: 3 | Pages: 8-15
DOI: https://doi.org/10.52403/ijrr.20260302
Potential Therapy for Damaged Kidney Tubule Cells Due to Aluminium Chloride Induction Using Human Wharton Jelly Mesenchymal Stem Cells
Qisthi Adwida Wavi1, Nita Afriani2, Endrinaldi3, Shinta Ayu Intan4, Hirowati Ali3, Dina Arfiani Rusjdi5
1Undergraduate Faculty of Medicine, Andalas University, Jl. Perintis Kemerdekaan No. 94, Padang, Indonesia.
2Department of Histology, Faculty of Medicine, Andalas University, Jl. Perintis Kemerdekaan No. 94, Padang, Indonesia.
3Department of Biomedical Science, Faculty of Medicine, Andalas University, Jl. Perintis Kemerdekaan No. 94, Padang, Indonesia.
4Department of Anatomy Patholoy, Faculty of Medicine, Andalas University, Jl. Perintis Kemerdekaan No. 94, Padang, Indonesia.
5Department of Radiology, Faculty of Medicine, Andalas University, Jl. Perintis Kemerdekaan No. 94, Padang, Indonesia.
Corresponding Author: Nita Afriani
ABSTRACT
Exposure to aluminium chloride (AlCl3) can occur through many different methods. Most of the aluminium will be excreted by the kidneys. Still, if the amount entering the body is high enough, it can lead to kidney dysfunction. This study uses AlCl3, which is nephrotoxic, so that it can damage renal tubular cells. The damage caused by AlCl3 can be overcome by human Wharton jelly mesenchymal stem cells (HWJMSCs), which are currently being developed as a therapy for tissue and cell repair because they have repair and anti-inflammatory agents against body tissues and cells.
This experimental study used 18 rats as experimental animals, divided into three groups. The first group received no treatment (negative control). The Second group was induced with AlCl3 (positive control). The third group was induced with AlCl3 and then given HWJMSCs (treatment). Renal tubular cell damage was analyzed using a one-way ANOVA, followed by a post hoc Bonferroni test. In the data obtained, the average percentage of cell damage was 40,71% (negative control), 72,89% (positive control), and 57,58% (treatment). Data analysis showed a significant difference between the positive and negative control groups (p = 0,001 (p < 0,005)), but no significant difference between the treatment group and positive control group (p = 0,061) and negative control group (p = 0,009). This study concludes that HWJMSCs play a role in repairing renal tubular cell damage, but this effect is not optimal.
Keywords: renal tubular cells; aluminium chloride (AlCl3); human Wharton jelly mesenchymal stem cells (HWJMSCs)
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