Year: 2024 | Month: August | Volume: 11 | Issue: 8 | Pages: 341-348
DOI: https://doi.org/10.52403/ijrr.20240836
A Brief Review on Bioisosterism in Drug Design and Designing of Advanced Drugs
Seba M C
Associate Professor, The Dale View College of Pharmacy and Research Centre, Punalal
ABSTRACT
This review predominantly focussed on the significance of bioisosterism in drug design and designing of novel advanced drugs. The broadest description of bioisosteres is, “molecules or groups those have chemical and physical similarities making broadly similar biological properties”.(1) There are two types of bioisosteres namely Classical and Non classical bioisosteres. A chief tendency in this area is the growing prevalence of “nonclassical isosteres” moieties those do not have the equal number of atoms, but produce a resemblance in a key parameter.(2)
Keywords: Bioisosteres, Lead molecule, Drug design, Docking.
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