Original Research Article
Year: 2023 | Month: August | Volume: 10 | Issue: 8 | Pages: 7-14
DOI: https://doi.org/10.52403/ijrr.20230802
Inflammation Markers (CRP, LDH, D-Dimer, Ferritin) As A Predictor of Death in COVID-19 Patients with Type 2 DM at H. Adam Malik Hospital
Cempaka Dewi NST1, Dian Anindita Lubis2, M. Aron Pase2
1Department of Internal Medicine, 2Division of Endocrine Department Internal Medicine,
Faculty of Medicine, University of North Sumatera, Medan, Indonesia
Corresponding Author: Cempaka Dewi NST
ABSTRACT
Introduction: Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both. Infectious diseases, including Coronavirus disease 2019 (COVID-19) are usually found more frequently and/or seriously in people with diabetes mellitus, and increase mortality. Hematological parameters, such as CRP, LDH, D-dimer, ferritin can help predicting death in COVID-19 patients with type 2 diabetes mellitus.
Aim: To determine the relationship of inflammatory markers (CRP, LDH, D-dimer, ferritin) with the incidence of death in COVID-19 patients with type 2 DM at H.Adam Malik General Hospital.
Method: This research was an observational analytic study using medical record data of patients at the central installation at H.Adam Malik Hospital from 2020-2021 period. The sample was total sampling. The distribution test was carried out with the Shapiro Wilk test. Bivariate analysis was carried out to determine the relationship between inflammatory markers (CRP, LDH, D-dimer, ferritin) and the incidence of death in COVID-19 patients with type 2 DM using the chi square test if the data were normally distributed, or Fisher's exact test if the data were not normally distributed and data were calculated using multivariate analysis. The desired deviation (α) is 0.05, statistically significant if p<0.05.
Results: 239 subjects were included in the study, majority were men with comorbid coronary heart disease and majority of patients survived. Ferritin, CRP and LDH levels in patients with confirmed COVID-19 with type 2 DM were not associated with death with p values of 0.503, 0.401 and 0.671, respectively. D-dimer levels and the degree of severity of COVID-19 in type 2 DM patients had a significant relationship to death (p=0.001).
Conclusion: D-dimer levels in patients with confirmed COVID-19 with type 2 DM were associated with death.
Keywords: diabetes mellitus, COVID-19, LDH, ferritin, D-dimer, CRP
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