Original Research Article
Year: 2023 | Month: February | Volume: 10 | Issue: 2 | Pages: 669-677
DOI: https://doi.org/10.52403/ijrr.20230281
Results of Analysis of Volatile Organic Compound (VOC) Measurements Using Breath Analyzer on Coronavirus Disease 2019 (COVID-19) Confirmed Patients with Healthy People
Susanthy Djajalaksana1, Caesar Ensang Timuda1, Jani Jane Rosihaningsih Sugiri1, Arinto Yudi Ponco Wardoyo2, Heri Sutanto3
1Department of Pulmonology and Respiratory, Faculty of Medicine, Brawijaya, University, Saiful Anwar Hospital, Indonesia, 65112
2Department of Physics, Faculty of Mathematics and Natural Sciences, Brawijaya University, Saiful Anwar Hospital, Indonesia, 65112
3Department of Internal Medicine, Faculty of Medicine, Brawijaya, University, Saiful Anwar Hospital, Indonesia, 65112
Corresponding Author: Caesar Ensang Timuda
ABSTRACT
Background/aim: The analysis of VOCs through respiration has been used for biomarker analysis for the detection of novel coronaviruses and has found mainly six VOCs by breath analysis by GC-IMS are ethanol, octane, acetone, cluster mixture of acetone/butanone and methanol. Previous research found exhaled methanol concentrations were lower in COVID-19 patients. The aim of this study was to analyze differences in VOC concentration in Covid-19 patients with healthy people.
Methods: This Case Control study used 93 confirmed case samples of Covid-19 and 42 healthy people. Demographic and clinical data taken from anamnesis and/or medical records. VOC’s data of respiratory track are taken through the exhalation air in a bag and analyzed with breath analyzer. Statistical analysis was conducted using Mann-Whitney test.
Results: VOC compound measured include CO2, C7H8, CH2O, NH4, TVOC, NO2, PM1.0, CO, NH3, and Acetone. Analysis between Covid-19 patients and healthy people showed significant differences in all VOC components CO2 (p=0,000), C7H8 (p=0,000), CH2O (p=0,000), NH4 (p=0,001), TVOC (p=0,000), NO2 (p=0,000), PM1.0 (p=0,000), CO (p=0,000), NH3 (P=0,000), Acetone (p=001). Logistic regression analysis was obtained no meaningful influence on each component of the VOC with covid/healthy people conditions of patients with components CO2 (p=1,000), C7H8 (p=1,000), CH2O (p=0,999), NH4 (p=1,000), TVOC (p=1,000), NO2 (p=1,000), PM1.0 (p=0,999), CO (p=0,999), NH3 (P=0,999), Acetone (p=1,000).
Conclusion: There is a significant difference between the VOC results of confirmed COVID 19 patients and healthy people
Keywords: breath analyzer, coronaviruses, COVID-19, healthy people, volatile organic component
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